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Target
Calcium-dependent protein kinase 4
Ligand
BDBM50383381
Substrate
n/a
Meas. Tech.
ChEBML_1734039
IC50
4.0±n/a nM
Citation
 Cabrera, DG; Horatscheck, A; Wilson, CR; Basarab, G; Eyermann, CJ; Chibale, K Plasmodial Kinase Inhibitors: License to Cure? J Med Chem 61:8061-8077 (2018) [PubMed]  Article 
Target
Name:
Calcium-dependent protein kinase 4
Synonyms:
CDPK4 | CDPK4_PLAF7 | CPK4
Type:
PROTEIN
Mol. Mass.:
60782.05
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_862298
Residue:
528
Sequence:
MGQEVSSVNNTKNEHHKTNKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVLHGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKLAQAALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKELLKLKGEDTSDLDNAAIEYEVDQILNSIDLDQNGYIEYSEFLTVSIDRKLLLSTERLEKAFKLFDKDGSGKISANELAQLFGLSDVSSECWKTVLKEVDQNNDGEIDFKEFRDMLVKLCNY
  
Inhibitor
Name:
BDBM50383381
Synonyms:
CHEMBL2030554 | CHEMBL2070050 | US10544104, Compound 29 | US11247972, Compound 29 | US9765037, Compound 29
Type:
Small organic molecule
Emp. Form.:
C23H26N6O
Mol. Mass.:
402.4921
SMILES:
CCOc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Structure:
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