Reaction Details Report a problem with these data
Target
Stromelysin-2
Ligand
BDBM50078196
Substrate
n/a
Meas. Tech.
ChEBML_1734200
IC50
4.0±n/a nM
Citation
 de Miguel, I; Orbe, J; Sánchez-Arias, JA; Rodríguez, JA; Salicio, A; Rabal, O; Belzunce, M; Sáez, E; Xu, M; Wu, W; Tan, H; Ma, H; Páramo, JA; Oyarzabal, J Phenotypic Screening To Discover Novel Chemical Series as Efficient Antihemorrhagic Agents. ACS Med Chem Lett 9:428-433 (2018) [PubMed]  Article 
Target
Name:
Stromelysin-2
Synonyms:
MMP10 | MMP10_HUMAN | Matrix Metalloproteinase-10 (MMP-10) | Matrix metalloproteinase 10 | STMY2
Type:
Enzyme
Mol. Mass.:
54143.02
Organism:
Homo sapiens (Human)
Description:
P09238
Residue:
476
Sequence:
MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
  
Inhibitor
Name:
BDBM50078196
Synonyms:
CHEMBL3417745
Type:
Small organic molecule
Emp. Form.:
C23H25F3N2O6S
Mol. Mass.:
514.515
SMILES:
ONC(=O)C1(CCC2(C1)CCNCC2)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: