Target
Renin
Ligand
BDBM50017799
Substrate
n/a
Meas. Tech.
ChEBML_195776
pH
7.2±n/a
IC50
900.0±n/a nM
Comments
extracted
Citation
 Allen, MCFuhrer, WTuck, BWade, RWood, JM Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus acid derivatives at the scissile bond. J Med Chem 32:1652-61 (1989) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50017799
Synonyms:
CHEMBL427576 | Z-Pro-Phe-His-LeuP(CH2)Val-Ala-Sta-OMe
Type:
Small organic molecule
Emp. Form.:
C51H75N8O12P
Mol. Mass.:
1023.1614
SMILES:
COC(=O)CC(O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C(CP(O)(=O)C(CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(C)C
Structure:
Search PDB for entries with ligand similarity: