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TargetCatechol-O-methyltransferase
LigandBDBM50017848
Substrate/Competitorn/a
Meas. Tech.ChEBML_47065
IC50 18±n/a nM
Citation Bäckström, RHonkanen, EPippuri, AKairisalo, PPystynen, JHeinola, KNissinen, ELinden, IBMännistö, PTKaakkola, S Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors. J Med Chem32:841-6 (1989) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Catechol-O-methyltransferase
Name:Catechol O-methyltransferase
Synonyms:n/a
Type:Enzyme
Mol. Mass.:29594.09
Organism:Rattus norvegicus (Rat)
Description:n/a
Residue:264
Sequence:
MPLAAVSLGLLLLALLLLLRHLGWGLVTIFWFEYVLQPVHNLIMGDTKEQRILRYVQQNA
KPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMA
RLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDM
VFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSY
LEYMKVVDGLEKAIYQGPSSPDKS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50017848
NameBDBM50017848
Synonyms:3-(3,4-Dihydroxy-5-nitro-benzylidene)-pentane-2,4-dione | CHEMBL167055 | Nitecapone
TypeSmall organic molecule
Emp. Form.C12H11NO6
Mol. Mass.265.2188
SMILES[#6]-[#6](=O)-[#6](=[#6]/c1cc(-[#8])c(-[#8])c(c1)-[#7+](-[#8-])=O)\[#6](-[#6])=O
Structure
n/a