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Target
Monoacylglycerol lipase ABHD6
Ligand
BDBM50408222
Substrate
n/a
Meas. Tech.
ChEMBL_1739439 (CHEMBL4155189)
IC50
530±n/a nM
Citation
 Chicca, A; Arena, C; Bertini, S; Gado, F; Ciaglia, E; Abate, M; Digiacomo, M; Lapillo, M; Poli, G; Bifulco, M; Macchia, M; Tuccinardi, T; Gertsch, J; Manera, C Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system. Eur J Med Chem 154:155-171 (2018) [PubMed]  Article 
Target
Name:
Monoacylglycerol lipase ABHD6
Synonyms:
2-arachidonoylglycerol hydrolase | ABHD6 | ABHD6_HUMAN | Abhydrolase domain-containing protein 6 | Monoacylglycerol lipase ABHD6
Type:
PROTEIN
Mol. Mass.:
38341.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105457
Residue:
337
Sequence:
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYVHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIDGQVKRIHQFVECLKLNKKPFHLVGTSMGGQVAGVYAAYYPSDVSSLCLVCPAGLQYSTDNQFVQRLKELQGSAAVEKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNNFYRKLFLEIVSEKSRYSLHQNMDKIKVPTQIIWGKQDQVLDVSGADMLAKSIANCQVELLENCGHSVVMERPRKTAKLIIDFLASVHNTDNNKKLD
  
Inhibitor
Name:
BDBM50408222
Synonyms:
CHEMBL4174442
Type:
Small organic molecule
Emp. Form.:
C21H24BrFN2O2
Mol. Mass.:
435.33
SMILES:
Cc1c(Br)cnc(OCc2ccc(F)cc2)c1C(=O)NC1CCCCCC1
Structure:
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