Reaction Details Report a problem with these data
Target
Vitamin K epoxide reductase complex subunit 1
Ligand
BDBM50018515
Substrate
n/a
Meas. Tech.
ChEBML_214476
Ki
16000±n/a nM
Citation
 Silverman, RB; Oliver, JS 2-(Fluoromethyl)-3-phytyl-1,4-naphthoquinone and its 2,3-epoxide. Inhibition of vitamin K epoxide reductase. J Med Chem 32:2138-41 (1989) [PubMed]  Article 
Target
Name:
Vitamin K epoxide reductase complex subunit 1
Synonyms:
VKOR1_BOVIN | VKORC1 | Vitamin k epoxide reductase complex subunit 1 isoform 1
Type:
PROTEIN
Mol. Mass.:
17977.60
Organism:
Bos taurus
Description:
ChEMBL_305987
Residue:
163
Sequence:
MGATWRSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGKDSILNQSNSIFGCIFYTLQLLLGCLQGRWASVLLRLSCLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVGLTVLSFREVQGPQGKVKGH
  
Inhibitor
Name:
BDBM50018515
Synonyms:
2-Fluoromethyl-2-hydroxy-3-methyl-3-(3,7,11,15-tetramethyl-hexadec-2-enyl)-2,3-dihydro-[1,4]naphthoquinone | CHEMBL67386
Type:
Small organic molecule
Emp. Form.:
C32H49FO3
Mol. Mass.:
500.7281
SMILES:
CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC1(C)C(=O)c2ccccc2C(=O)C1(O)CF
Structure:
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