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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50450130
Substrate
n/a
Meas. Tech.
ChEMBL_1742220 (CHEMBL4157970)
EC50
68±n/a nM
Citation
 Shinozuka, T; Tsukada, T; Fujii, K; Tokumaru, E; Shimada, K; Onishi, Y; Matsui, Y; Wakimoto, S; Kuroha, M; Ogata, T; Araki, K; Ohsumi, J; Sawamura, R; Watanabe, N; Yamamoto, H; Fujimoto, K; Tani, Y; Mori, M; Tanaka, J Discovery of DS-6930, a potent selective PPAR? modulator. Part II: Lead optimization. Bioorg Med Chem 26:5099-5117 (2018) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50450130
Synonyms:
CHEMBL4164753
Type:
Small organic molecule
Emp. Form.:
C22H16ClFN2O4
Mol. Mass.:
426.825
SMILES:
Cn1c(COc2cccc(c2)C(O)=O)nc2ccc(Oc3ccc(Cl)c(F)c3)cc12
Structure:
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