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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50450156
Substrate
n/a
Meas. Tech.
ChEMBL_1742299 (CHEMBL4158049)
EC50
4330±n/a nM
Citation
 Chen, SR; Li, F; Ding, MY; Wang, D; Zhao, Q; Wang, Y; Zhou, GC; Wang, Y Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice. Bioorg Med Chem 26:5053-5061 (2018) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3)
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Homo sapiens (Human)
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50450156
Synonyms:
CHEMBL1933810
Type:
Small organic molecule
Emp. Form.:
C28H46O6Si
Mol. Mass.:
506.7467
SMILES:
[H][C@]12[#6]-[#6]-[#6](=[#6])-[#6@@H](-[#6]\[#6]=[#6]-3/[#6@@H](-[#6]-[#8]-[#6]-3=O)-[#8]-[#6](-[#6])=O)[C@]1([#6])[#6]-[#6]-[#6@@H](-[#8])[C@@]2([#6])[#6]-[#8][Si;v4]([#6])([#6])C([#6])([#6])[#6] |r|
Structure:
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