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Target
Mu-type opioid receptor
Ligand
BDBM50019480
Substrate
n/a
Meas. Tech.
ChEBML_148716
Ki
0.580000±n/a nM
Citation
 Gairin, JE; Mazarguil, H; Alvinerie, P; Saint-Pierre, S; Meunier, JC; Cros, J Synthesis and biological activities of dynorphin A analogues with opioid antagonist properties. J Med Chem 29:1913-7 (1986) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50019480
Synonyms:
CHEMBL2373009 | NH2-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Trp-Arg-D-Pro-Lys-OH
Type:
Small organic molecule
Emp. Form.:
C68H102N22O13
Mol. Mass.:
1435.6771
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(O)=O |wU:4.4,76.79,51.52,94.98,wD:90.95,62.63,40.41,8.16,27.28,(-1.12,-19.2,;-1.46,-17.7,;-2.93,-17.24,;-.32,-16.66,;-.66,-15.15,;.47,-14.11,;1.94,-14.57,;2.28,-16.07,;3.07,-13.52,;2.73,-12.02,;1.26,-11.56,;.92,-10.06,;-.55,-9.6,;-1.68,-10.65,;-1.34,-12.15,;.13,-12.61,;4.54,-13.98,;5.67,-12.93,;5.33,-11.43,;7.14,-13.39,;8.27,-12.35,;9.74,-12.8,;10.08,-14.3,;10.87,-11.76,;12.34,-12.21,;13.48,-11.17,;13.14,-9.67,;14.95,-11.63,;15.29,-13.13,;16.08,-10.58,;17.55,-11.04,;18.68,-9.99,;20.15,-10.45,;20.49,-11.95,;21.96,-12.41,;19.36,-13,;17.89,-12.54,;-2.13,-14.7,;-2.47,-13.19,;-3.27,-15.74,;-4.74,-15.28,;-5.08,-13.78,;-3.94,-12.74,;-4.28,-11.23,;-3.15,-10.19,;-3.49,-8.69,;-2.36,-7.64,;-4.96,-8.23,;-5.87,-16.33,;-5.53,-17.83,;-7.34,-15.87,;-8.47,-16.92,;-8.13,-18.42,;-9.26,-19.46,;-8.92,-20.97,;-10.05,-22.01,;-9.71,-23.51,;-10.84,-24.56,;-8.24,-23.97,;-9.94,-16.46,;-10.28,-14.96,;-11.07,-17.5,;-12.54,-17.05,;-13.67,-18.09,;-15.14,-17.64,;-15.64,-16.18,;-17.18,-16.2,;-17.64,-17.67,;-19.03,-18.31,;-19.18,-19.84,;-17.92,-20.73,;-16.52,-20.09,;-16.38,-18.56,;-12.88,-15.55,;-14.35,-15.09,;-11.75,-14.5,;-12.09,-13,;-13.56,-12.54,;-13.9,-11.04,;-15.37,-10.58,;-15.71,-9.08,;-17.18,-8.62,;-17.52,-7.12,;-18.31,-9.67,;-10.96,-11.95,;-9.49,-12.41,;-11.3,-10.45,;-12.71,-9.84,;-12.57,-8.31,;-11.07,-7.97,;-10.28,-9.29,;-8.75,-9.43,;-8.1,-10.83,;-7.86,-8.18,;-6.33,-8.32,;-5.44,-7.06,;-3.9,-7.2,;-3.01,-5.95,;-1.48,-6.09,;-.59,-4.83,;-5.68,-9.72,;-6.57,-10.98,;-4.15,-9.86,)|
Structure:
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