Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50452462
Substrate
n/a
Meas. Tech.
ChEMBL_1747592 (CHEMBL4182102)
EC50
1800±n/a nM
Citation
 Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem 25:6680-6694 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
4.6.1.2 | ANP-A | ANPR-A | ANPRA_RAT | Atrial natriuretic peptide receptor 1 | Atrial natriuretic peptide receptor type A | GC-A | Guanylate cyclase A | NPR-A | Npr1
Type:
PROTEIN
Mol. Mass.:
118956.96
Organism:
Rattus norvegicus
Description:
ChEMBL_18039
Residue:
1057
Sequence:
MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG
  
Inhibitor
Name:
BDBM50452462
Synonyms:
CHEMBL4217505
Type:
Small organic molecule
Emp. Form.:
C28H35FN6O2
Mol. Mass.:
506.6149
SMILES:
COC[C@H](C)Nc1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)NC2CC2)c2cc(ccc2n1)-c1cccc(F)c1 |r,wU:10.9,13.16,wD:3.3,(19.08,-4.75,;17.75,-5.51,;16.43,-4.73,;15.1,-5.48,;15.1,-7.01,;13.79,-4.72,;12.45,-5.48,;12.44,-7.02,;11.11,-7.78,;11.1,-9.32,;12.43,-10.1,;12.42,-11.64,;13.75,-12.42,;15.09,-11.65,;15.09,-10.11,;13.77,-9.34,;16.41,-12.43,;17.75,-11.67,;17.75,-10.15,;19.07,-12.44,;20.4,-11.68,;21.93,-11.69,;21.17,-10.36,;9.78,-7,;8.44,-7.77,;7.11,-6.99,;7.11,-5.45,;8.46,-4.69,;9.79,-5.46,;11.12,-4.7,;5.77,-7.76,;5.76,-9.3,;4.43,-10.06,;3.1,-9.28,;3.1,-7.74,;1.78,-6.97,;4.44,-6.98,)|
Structure:
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