Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50020002
Substrate
n/a
Meas. Tech.
ChEBML_58532
IC50
34±n/a nM
Citation
 New, JS; Yevich, JP; Temple, DL; New, KB; Gross, SM; Schlemmer, RF; Eison, MS; Taylor, DP; Riblet, LA Atypical antipsychotic agents: patterns of activity in a series of 3-substituted 2-pyridinyl-1-piperazine derivatives. J Med Chem 31:618-24 (1988) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50020002
Synonyms:
2-{4-[4-(2,4-Dioxo-1-thia-3-aza-spiro[4.4]non-3-yl)-butyl]-piperazin-1-yl}-nicotinonitrile | CHEMBL348150
Type:
Small organic molecule
Emp. Form.:
C21H27N5O2S
Mol. Mass.:
413.536
SMILES:
O=C1SC2(CCCC2)C(=O)N1CCCCN1CCN(CC1)c1ncccc1C#N
Structure:
Search PDB for entries with ligand similarity: