Reaction Details
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DNA-(apurinic or apyrimidinic site) endonuclease
Ligand
BDBM50453739
Substrate
n/a
Meas. Tech.
ChEMBL_1750384 (CHEMBL4185144)
IC50
1800±n/a nM
Citation
Laev, SS; Salakhutdinov, NF; Lavrik, OI Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1). Bioorg Med Chem 25:2531-2544 (2017) [PubMed] Article More Info.:
Target
Name:
DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:
APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:
Protein
Mol. Mass.:
35560.12
Organism:
Homo sapiens (Human)
Description:
P27695
Residue:
318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
Inhibitor
Name:
BDBM50453739
Synonyms:
CHEMBL4207384
Type:
Small organic molecule
Emp. Form.:
C24H14Cl4O6S2
Mol. Mass.:
604.306
SMILES:
Clc1ccc(cc1Cl)S(=O)(=O)Oc1ccc(cc1)-c1ccc(OS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1
Structure:
