Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50454059
Substrate
n/a
Meas. Tech.
ChEMBL_1751765 (CHEMBL4186525)
EC50
36±n/a nM
Citation
 Kinoshita, A; Higashino, M; Yoshida, K; Aratani, Y; Kakuuchi, A; Hanada, K; Takeda, H; Naganawa, A; Matsuya, H; Ohmoto, K Synthesis and evaluation of a potent, well-balanced EP Bioorg Med Chem 26:200-214 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50454059
Synonyms:
CHEMBL4207054
Type:
Small organic molecule
Emp. Form.:
C22H32N2O5S2
Mol. Mass.:
468.63
SMILES:
C[C@@H]1OC(=O)N(CCSc2nc(cs2)C(O)=O)[C@H]1\C=C\CC(C)(O)CC1CCCCC1 |r|
Structure:
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