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Target
Aromatase
Ligand
BDBM50273776
Substrate
n/a
Meas. Tech.
ChEMBL_1752053 (CHEMBL4186813)
IC50
100±n/a nM
Citation
 Meyers, K; Cogan, DA; Burke, J; Arenas, R; Balestra, M; Brown, NF; Chen, Z; Cerny, MA; Clifford, HE; Colombo, F; Fader, L; Frederick, KS; Guo, X; Goldberg, D; Hornberger, KR; Kugler, S; Lord, J; Marshall, DR; Moss, N; Parmentier, JH; Richman, JR; Schmenk, J; Weldon, SM; Yu, M; Zhang, M Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity. Bioorg Med Chem Lett 28:979-984 (2018) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50273776
Synonyms:
1-Methyl-6-pyridin-3-yl-3,4-dihydroquinolin-2(1H)-one | CHEMBL446083
Type:
Small organic molecule
Emp. Form.:
C15H14N2O
Mol. Mass.:
238.2845
SMILES:
CN1C(=O)CCc2cc(ccc12)-c1cccnc1
Structure:
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