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Target
Midkine
Ligand
BDBM50454863
Substrate
n/a
Meas. Tech.
ChEMBL_1753624 (CHEMBL4188384)
IC50
396±n/a nM
Citation
 Maza, S; Gandia-Aguado, N; de Paz, JL; Nieto, PM Fluorous-tag assisted synthesis of a glycosaminoglycan mimetic tetrasaccharide as a high-affinity FGF-2 and midkine ligand. Bioorg Med Chem 26:1076-1085 (2018) [PubMed]  Article 
Target
Name:
Midkine
Synonyms:
ARAP | Amphiregulin-associated protein | MDK | MK | MK1 | MK_HUMAN | Midgestation and kidney protein | NEGF2 | Neurite outgrowth-promoting factor 2 | Neurite outgrowth-promoting protein
Type:
PROTEIN
Mol. Mass.:
15605.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_805023
Residue:
143
Sequence:
MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD
  
Inhibitor
Name:
BDBM50454863
Synonyms:
CHEMBL4206352
Type:
Small organic molecule
Emp. Form.:
C57H50F17NO23S2
Mol. Mass.:
1504.103
SMILES:
COc1ccc(O[C@@H]2O[C@H](COC(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)[C@@H](O[C@@H]3O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OC(=O)CCC(C)=O)[C@H]3N3C(=O)c4ccccc4C3=O)[C@H](OCc3ccccc3)[C@H]2OC(=O)c2ccccc2)cc1 |r|
Structure:
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