Reaction Details
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cAMP-dependent protein kinase type II-beta regulatory subunit
Ligand
BDBM50455159
Substrate
n/a
Meas. Tech.
ChEMBL_1753987 (CHEMBL4188747)
Kd
557±n/a nM
Citation
Bendzunas, NG; Dörfler, S; Autenrieth, K; Bertinetti, D; Machal, EMF; Kennedy, EJ; Herberg, FW Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg Med Chem 26:1174-1178 (2018) [PubMed] Article More Info.:
Target
Name:
cAMP-dependent protein kinase type II-beta regulatory subunit
Synonyms:
KAP3_HUMAN | PRKAR2B
Type:
PROTEIN
Mol. Mass.:
46282.41
Organism:
Homo sapiens (Human)
Description:
EBI_11972
Residue:
418
Sequence:
MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA
Inhibitor
Name:
BDBM50455159
Synonyms:
CHEMBL4205523
Type:
Small organic molecule
Emp. Form.:
C99H175N23O23
Mol. Mass.:
2055.5891
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)COCCOCCOCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@]1(C)CCC\C=C\CCC[C@](C)(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(O)=O |r,t:92|
Structure:
