Target
Retinoic acid receptor gamma
Ligand
BDBM50457541
Substrate
n/a
Meas. Tech.
ChEMBL_1760055 (CHEMBL4195063)
EC50
7.4±n/a nM
Citation
 Thoreau, EArlabosse, JMBouix-Peter, CChambon, SChantalat, LDaver, SDumais, LDuvert, GFeret, AOuvry, GPascau, JRaffin, CRodeville, NSoulet, CTabet, STalano, SPortal, T Structure-based design of Trifarotene (CD5789), a potent and selective RAR? agonist for the treatment of acne. Bioorg Med Chem Lett 28:1736-1741 (2018) [PubMed]  Article 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM50457541
Synonyms:
CHEMBL4216161
Type:
Small organic molecule
Emp. Form.:
C32H38O5
Mol. Mass.:
502.6411
SMILES:
COCCOCOc1ccc(cc1-c1ccc2c(c1)C(C)(C)CCC2(C)C)-c1ccc(C(O)=O)c(C)c1
Structure:
Search PDB for entries with ligand similarity: