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TargetDNA topoisomerase III
LigandBDBM50022163
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54523
Ki 400±n/a nM
Citation Trantolo, DJWright, GEBrown, NC Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem29:676-81 (1986) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA topoisomerase III
Name:DNA topoisomerase III
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:81515.22
Organism:Bacillus subtilis
Description:ChEMBL_54525
Residue:727
Sequence:
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQS
WRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEK
ANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTT
KFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFN
QDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQK
LYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDA
KVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFT
AKGKTVQSQGWKAVYDMAEEDDEQEDDRDQTLPALQKGDTLAVRTLTETSGQTKPPARFN
EGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKGQDIFI
TSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSS
QTFRHDNITGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRME
LRGQGEGQTFACVCGHREKLSVFEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQL
KKLGLDK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50022163
NameBDBM50022163
Synonyms:6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione | CHEMBL54950
TypeSmall organic molecule
Emp. Form.C13H13N3O2
Mol. Mass.243.2612
SMILESO=c1cc(Nc2ccc3CCCc3c2)[nH]c(=O)[nH]1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a