Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50022529
Substrate
n/a
Meas. Tech.
ChEBML_196420
IC50
>100000±n/a nM
Citation
 Iizuka, K; Kamijo, T; Kubota, T; Akahane, K; Umeyama, H; Kiso, Y New human renin inhibitors containing an unnatural amino acid, norstatine. J Med Chem 31:701-4 (1988) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
RENI_RAT | Ren | Ren1
Type:
PROTEIN
Mol. Mass.:
44272.67
Organism:
Rattus norvegicus
Description:
ChEMBL_222765
Residue:
402
Sequence:
MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
  
Inhibitor
Name:
BDBM50022529
Synonyms:
2-Hydroxy-3-[3-(1H-imidazol-4-yl)-2-(2-naphthalen-1-ylmethyl-4-oxo-4-piperidin-1-yl-butyrylamino)-propionylamino]-5-methyl-hexanoic acid methyl ester | CHEMBL159336
Type:
Small organic molecule
Emp. Form.:
C34H45N5O6
Mol. Mass.:
619.751
SMILES:
COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)N1CCCCC1)Cc1cccc2ccccc12
Structure:
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