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Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
Ligand
BDBM50028309
Substrate
n/a
Meas. Tech.
ChEMBL_1766161 (CHEMBL4201408)
IC50
64±n/a nM
Citation
 Wang, X; Edwards, RL; Ball, H; Johnson, C; Haymond, A; Girma, M; Manikkam, M; Brothers, RC; McKay, KT; Arnett, SD; Osbourn, DM; Alvarez, S; Boshoff, HI; Meyers, MJ; Couch, RD; Odom John, AR; Dowd, CS MEPicides: ?,?-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria. J Med Chem 61:8847-8858 (2018) [PubMed]  Article 
Target
Name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
Synonyms:
1-deoxyxylulose-5-phosphate reductoisomerase | DOXP reductoisomerase | DXP reductoisomerase | DXR | DXR_PLAF7
Type:
PROTEIN
Mol. Mass.:
55772.75
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_117864
Residue:
488
Sequence:
MKKYIYIYFFFITITINDLVINNTSKCVSIERRKNNAYINYGIGYNGPDNKITKSRRCKRIKLCKKDLIDIGAIKKPINVAIFGSTGSIGTNALNIIRECNKIENVFNVKALYVNKSVNELYEQAREFLPEYLCIHDKSVYEELKELVKNIKDYKPIILCGDEGMKEICSSNSIDKIVIGIDSFQGLYSTMYAIMNNKIVALANKESIVSAGFFLKKLLNIHKNAKIIPVDSEHSAIFQCLDNNKVLKTKCLQDNFSKINNINKIFLCSSGGPFQNLTMDELKNVTSENALKHPKWKMGKKITIDSATMMNKGLEVIETHFLFDVDYNDIEVIVHKECIIHSCVEFIDKSVISQMYYPDMQIPILYSLTWPDRIKTNLKPLDLAQVSTLTFHKPSLEHFPCIKLAYQAGIKGNFYPTVLNASNEIANNLFLNNKIKYFDISSIISQVLESFNSQKVSENSEDLMKQILQIHSWAKDKATDIYNKHNSS
  
Inhibitor
Name:
BDBM50028309
Synonyms:
Fosmidomycin Sodium
Type:
Small organic molecule
Emp. Form.:
C4H9NNaO5P
Mol. Mass.:
205.0815
SMILES:
[Na+].ON(CCCP(O)([O-])=O)C=O
Structure:
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