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Target
Falcipain 2
Ligand
BDBM50461234
Substrate
n/a
Meas. Tech.
ChEMBL_1770953 (CHEMBL4223065)
IC50
4200±n/a nM
Citation
 Himangini, na; Pathak, DP; Sharma, V; Kumar, S Designing novel inhibitors against falcipain-2 of Plasmodium falciparum. Bioorg Med Chem Lett 28:1566-1569 (2018) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50461234
Synonyms:
CHEMBL4226443
Type:
Small organic molecule
Emp. Form.:
C29H26FN3O3
Mol. Mass.:
483.5334
SMILES:
CCN(CC)c1ccc2cc(C3=NN(C(C3)c3ccc(F)cc3)C(=O)c3ccccc3)c(=O)oc2c1 |t:11|
Structure:
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