Reaction Details Report a problem with these data
Target
Falcipain-2
Ligand
BDBM50461232
Substrate
n/a
Meas. Tech.
ChEMBL_1770954 (CHEMBL4223066)
IC50
33800±n/a nM
Citation
 Himangini, na; Pathak, DP; Sharma, V; Kumar, S Designing novel inhibitors against falcipain-2 of Plasmodium falciparum. Bioorg Med Chem Lett 28:1566-1569 (2018) [PubMed]  Article 
Target
Name:
Falcipain-2
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
55912.57
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50461232
Synonyms:
CHEMBL4227123
Type:
Small organic molecule
Emp. Form.:
C28H26FN3O2
Mol. Mass.:
455.5233
SMILES:
CCN(CC)c1ccc2cc(C3=NN(C(C3)c3ccc(F)cc3)c3ccccc3)c(=O)oc2c1 |t:11|
Structure:
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