Reaction Details Report a problem with these data
Target
Myc proto-oncogene protein
Ligand
BDBM50463138
Substrate
n/a
Meas. Tech.
ChEMBL_1777746 (CHEMBL4234738)
IC50
3000±n/a nM
Citation
 Jacob, NT; Miranda, PO; Shirey, RJ; Gautam, R; Zhou, B; de Orbe Izquierdo, ME; Hixon, MS; Hart, JR; Ueno, L; Vogt, PK; Janda, KD Synthetic molecules for disruption of the MYC protein-protein interface. Bioorg Med Chem 26:4234-4239 (2018) [PubMed]  Article 
Target
Name:
Myc proto-oncogene protein
Synonyms:
BHLHE39 | Class E basic helix-loop-helix protein 39 | MYC | MYC_HUMAN | Proto-oncogene c-Myc | Transcription factor p64
Type:
PROTEIN
Mol. Mass.:
48794.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_935266
Residue:
439
Sequence:
MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
  
Inhibitor
Name:
BDBM50463138
Synonyms:
CHEMBL4240401
Type:
Small organic molecule
Emp. Form.:
C23H15N3O2
Mol. Mass.:
365.3841
SMILES:
NC(=O)c1ccc(cc1)-c1cc(nc(c1)-c1ccc(cc1)C#N)-c1ccco1
Structure:
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