Reaction Details Report a problem with these data
Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50142500
Substrate
n/a
Meas. Tech.
ChEMBL_1777837 (CHEMBL4234829)
IC50
170000±n/a nM
Citation
Chien, HC; Colas, C; Finke, K; Springer, S; Stoner, L; Zur, AA; Venteicher, B; Campbell, J; Hall, C; Flint, A; Augustyn, E; Hernandez, C; Heeren, N; Hansen, L; Anthony, A; Bauer, J; Fotiadis, D; Schlessinger, A; Giacomini, KM; Thomas, AA Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem 61:7358-7373 (2018) [PubMed] Article
More Info.:
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
Inhibitor
Name:
BDBM50142500
Synonyms:
(2S)-2-amino-4-(methylsulfanyl)butanoic acid | (S)-2-amino-4-(methylthio)butanoic acid | (S)-2-amino-4-(methylthio)butyric acid | (S)-methionine | CHEMBL42336 | L-(-)-methionine | L-Methionin | L-alpha-amino-gamma-methylmercaptobutyric acid | L-methionine | US11021454, Compound L-met
Type:
Small organic molecule
Emp. Form.:
C5H11NO2S
Mol. Mass.:
149.211
SMILES:
CSCC[C@H](N)C(O)=O |r|