Reaction Details Report a problem with these data
Target
Cellular tumor antigen p53
Ligand
BDBM50463356
Substrate
n/a
Meas. Tech.
ChEMBL_1778144 (CHEMBL4235136)
EC50
74±n/a nM
Citation
 Okolotowicz, KJ; Dwyer, M; Ryan, D; Cheng, J; Cashman, EA; Moore, S; Mercola, M; Cashman, JR Novel tertiary sulfonamides as potent anti-cancer agents. Bioorg Med Chem 26:4441-4451 (2018) [PubMed]  Article 
Target
Name:
Cellular tumor antigen p53
Synonyms:
Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53
Type:
fusion protein
Mol. Mass.:
43654.73
Organism:
Homo sapiens (Human)
Description:
The full-length His6-wt-p53 expressed in E. coli was used in assays.
Residue:
393
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
  
Inhibitor
Name:
BDBM50463356
Synonyms:
CHEMBL4240141
Type:
Small organic molecule
Emp. Form.:
C18H20N4O2S
Mol. Mass.:
356.442
SMILES:
CN1CCN(c2ccccc12)S(=O)(=O)c1ccc(cc1)N1CCC=N1 |c:26|
Structure:
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