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TargetSerine/threonine-protein kinase NEK2
LigandBDBM50463483
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1778404
Ki>2000±n/a nM
Citation Bandarage, UKCao, JCome, JHCourt, JJGao, HJacobs, MDMarhefka, CNanthakumar, SGreen, J ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors. Bioorg Med Chem Lett28:2622-2626 (2018) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase NEK2
Name:Serine/threonine-protein kinase NEK2
Synonyms:NEK2
Type:Enzyme
Mol. Mass.:51776.96
Organism:Homo sapiens (Human)
Description:P51955
Residue:445
Sequence:
MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50463483
NameBDBM50463483
Synonyms:CHEMBL4245242
TypeSmall organic molecule
Emp. Form.C26H29N5O2S
Mol. Mass.475.606
SMILESO=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a