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Target
2-5A-dependent ribonuclease
Ligand
BDBM50025000
Substrate
n/a
Meas. Tech.
ChEMBL_164143 (CHEMBL771467)
IC50
250±n/a nM
Citation
 Lesiak, K; Torrence, PF Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine. J Med Chem 29:1015-22 (1986) [PubMed]  Article 
Target
Name:
2-5A-dependent ribonuclease
Synonyms:
2-5A-dependent RNase | 2-5A-dependent ribonuclease | RN5A_MOUSE | RNase L | Ribonuclease 4 | Ribonuclease L | Rnasel | Rns4
Type:
PROTEIN
Mol. Mass.:
83274.00
Organism:
Mus musculus
Description:
ChEMBL_195099
Residue:
735
Sequence:
METPDYNTPQGGTPSAGSQRTVVEDDSSLIKAVQKGDVVRVQQLLEKGADANACEDTWGWTPLHNAVQAGRVDIVNLLLSHGADPHRRKKNGATPFIIAGIQGDVKLLEILLSCGADVNECDENGFTAFMEAAERGNAEALRFLFAKGANVNLRRQTTKDKRRLKQGGATALMSAAEKGHLEVLRILLNDMKAEVDARDNMGRNALIRTLLNWDCENVEEITSILIQHGADVNVRGERGKTPLIAAVERKHTGLVQMLLSREGINIDARDNEGKTALLIAVDKQLKEIVQLLLEKGADKCDDLVWIARRNHDYHLVKLLLPYVANPDTDPPAGDWSPHSSRWGTALKSLHSMTRPMIGKLKIFIHDDYKIAGTSEGAVYLGIYDNREVAVKVFRENSPRGCKEVSCLRDCGDHSNLVAFYGREDDKGCLYVCVSLCEWTLEEFLRLPREEPVENGEDKFAHSILLSIFEGVQKLHLHGYSHQDLQPQNILIDSKKAVRLADFDQSIRWMGESQMVRRDLEDLGRLVLYVVMKGEIPFETLKTQNDEVLLTMSPDEETKDLIHCLFSPGENVKNCLVDLLGHPFFWTWENRYRTLRNVGNESDIKVRKCKSDLLRLLQHQTLEPPRSFDQWTSKIDKNVMDEMNHFYEKRKKNPYQDTVGDLLKFIRNIGEHINEEKKRGMKEILGDPSRYFQETFPDLVIYIYKKLKETEYRKHFPQPPPRLSVPEAVGPGGIQS
  
Inhibitor
Name:
BDBM50025000
Synonyms:
CHEMBL3143409 | ppp5'(br8A)2'p5'(br8A)2'p5'(br8A)
Type:
Small organic molecule
Emp. Form.:
C50H59Br5N25O37P7
Mol. Mass.:
2218.485
SMILES:
Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(=O)O[C@@H]7[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]7n7c(Br)nc8c(N)ncnc78)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r|
Structure:
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