Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 4
Ligand
BDBM50466543
Substrate
n/a
Meas. Tech.
ChEMBL_1793347 (CHEMBL4265266)
EC50
0.100000±n/a nM
Citation
 Østergaard, S; Kofoed, J; Paulsson, JF; Madsen, KG; Jorgensen, R; Wulff, BS Design of Y J Med Chem 61:10519-10530 (2018) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 4
Synonyms:
NPY4-R | NPY4R_MOUSE | NPYR-D | Neuropeptide Y receptor type 4 | Npy4r | PP1 | Pancreatic polypeptide receptor 1 | Ppyr1
Type:
PROTEIN
Mol. Mass.:
42658.42
Organism:
Mus musculus
Description:
ChEMBL_117341
Residue:
375
Sequence:
MNTSHFLAPLFPGSLQGKNGTNPLDSPYNFSDGCQDSAELLAFIITTYSIETILGVLGNLCLIFVTTRQKEKSNVTNLLIANLAFSDFLMCLICQPLTVTYTIMDYWIFGEVLCKMLTFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSIFQAYLGIVVIWFVSCFLSLPFLANSTLNDLFHYNHSKVVEFLEDKVVCFVSWSSDHHRLIYTTFLLLFQYCIPLAFILVCYIRIYQRLQRQKHVFHAHACSSRAGQMKRINSMLMTMVTAFAVLWLPLHVFNTLEDWYQEAIPACHGNLIFLMCHLLAMASTCVNPFIYGFLNINFKKDIKALVLTCHCRSPRGESEHLPLSTVHTDLSKGSMRMGSKSNFI
  
Inhibitor
Name:
BDBM50466543
Synonyms:
CHEMBL4276961
Type:
Small organic molecule
Emp. Form.:
C185H286N52O55S2
Mol. Mass.:
4182.696
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O |r|
Structure:
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