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Target
Heme oxygenase 1
Ligand
BDBM50438651
Substrate
n/a
Meas. Tech.
ChEMBL_1796598 (CHEMBL4268715)
IC50
1000±n/a nM
Citation
 Sorrenti, V; Pittalą, V; Romeo, G; Amata, E; Dichiara, M; Marrazzo, A; Turnaturi, R; Prezzavento, O; Barbagallo, I; Vanella, L; Rescifina, A; Floresta, G; Tibullo, D; Di Raimondo, F; Intagliata, S; Salerno, L Targeting heme Oxygenase-1 with hybrid compounds to overcome Imatinib resistance in chronic myeloid leukemia cell lines. Eur J Med Chem 158:937-950 (2018) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50438651
Synonyms:
CHEMBL2414454
Type:
Small organic molecule
Emp. Form.:
C13H15IN2O
Mol. Mass.:
342.1755
SMILES:
Ic1ccc(OCCCCn2ccnc2)cc1
Structure:
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