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Target
MAP/microtubule affinity-regulating kinase 4
Ligand
BDBM50467763
Substrate
n/a
Meas. Tech.
ChEMBL_1796954 (CHEMBL4269071)
IC50
5560±n/a nM
Citation
 Parveen, I; Khan, P; Ali, S; Hassan, MI; Ahmed, N Synthesis, molecular docking and inhibition studies of novel 3-N-aryl substituted-2-heteroarylchromones targeting microtubule affinity regulating kinase 4 inhibitors. Eur J Med Chem 159:166-177 (2018) [PubMed]  Article 
Target
Name:
MAP/microtubule affinity-regulating kinase 4
Synonyms:
KIAA1860 | MAP/microtubule affinity-regulating kinase 4 | MARK4 | MARK4_HUMAN | MARKL1
Type:
PROTEIN
Mol. Mass.:
82561.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774620
Residue:
752
Sequence:
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
  
Inhibitor
Name:
BDBM50467763
Synonyms:
CHEMBL4279484
Type:
Small organic molecule
Emp. Form.:
C20H15NO4
Mol. Mass.:
333.3374
SMILES:
COc1ccc(Nc2c(oc3ccccc3c2=O)-c2ccco2)cc1
Structure:
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