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Target
Dopamine beta-hydroxylase
Ligand
BDBM50026182
Substrate
n/a
Meas. Tech.
ChEBML_59141
Ki
21000±n/a nM
Citation
 Bargar, TM; Broersma, RJ; Creemer, LC; McCarthy, JR; Hornsperger, JM; Palfreyman, MG; Wagner, J; Jung, MJ Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine beta-hydroxylase. J Med Chem 29:315-7 (1986) [PubMed]  Article 
Target
Name:
Dopamine beta-hydroxylase
Synonyms:
DBH | DOPO_BOVIN
Type:
PROTEIN
Mol. Mass.:
68136.39
Organism:
Bos taurus
Description:
ChEMBL_50738
Residue:
610
Sequence:
MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISYAQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDSQQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSGLHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMELGLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARDGRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSFNREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGPTVLNISGGKG
  
Inhibitor
Name:
BDBM50026182
Synonyms:
3-Phenyl-prop-2-ynylamine | CHEMBL110611 | US9161922, Table 1, Compound 3
Type:
Small organic molecule
Emp. Form.:
C9H9N
Mol. Mass.:
131.1745
SMILES:
NCC#Cc1ccccc1
Structure:
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