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Target
Protein mono-ADP-ribosyltransferase PARP12
Ligand
BDBM50452662
Substrate
n/a
Meas. Tech.
ChEMBL_1800458 (CHEMBL4272750)
IC50
>10000±n/a nM
Citation
 Murthy, S; Desantis, J; Verheugd, P; Maksimainen, MM; Venkannagari, H; Massari, S; Ashok, Y; Obaji, E; Nkizinkinko, Y; Lüscher, B; Tabarrini, O; Lehtiö, L 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem 156:93-102 (2018) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP12
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1
Type:
PROTEIN
Mol. Mass.:
79092.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107665
Residue:
701
Sequence:
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
  
Inhibitor
Name:
BDBM50452662
Synonyms:
CHEMBL4208737
Type:
Small organic molecule
Emp. Form.:
C14H12FNO2
Mol. Mass.:
245.249
SMILES:
NC(=O)c1ccc(OCc2ccccc2F)cc1
Structure:
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