Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Ligand
BDBM50470779
Substrate
n/a
Meas. Tech.
ChEMBL_157200 (CHEMBL767095)
IC50
15±n/a nM
Citation
 Duplantier, AJBiggers, MSChambers, RJCheng, JBCooper, KDamon, DBEggler, JFKraus, KGMarfat, AMasamune, HPillar, JSShirley, JTUmland, JPWatson, JW Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret. J Med Chem 39:120-5 (1996) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Synonyms:
DPDE3 | PDE4D_MOUSE | Pde4d
Type:
PROTEIN
Mol. Mass.:
84520.85
Organism:
Mus musculus
Description:
ChEMBL_105062
Residue:
747
Sequence:
MERDTCDVLSRSKSASEETLHSCNEEEDPFRGMEPYLVRRLSSRSIQLPPLAFRQLEQADLRSESENIPRPTSLPLKILPLIAVTSADSSGFDVDNGTSAGRSPLDPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSCIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDQEEGRQGQTEKFQFELTLEEDCESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVAEEESQPETCVPDDCCPDT
  
Inhibitor
Name:
BDBM50470779
Synonyms:
CHEMBL21463
Type:
Small organic molecule
Emp. Form.:
C19H20O4
Mol. Mass.:
312.3597
SMILES:
COc1ccc(cc1OC1CCCC1)-c1cccc(c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: