Reaction Details Report a problem with these data
Target
Urokinase-type plasminogen activator
Ligand
BDBM50027288
Substrate
n/a
Meas. Tech.
ChEBML_212984
Ki
17800±n/a nM
Citation
 Tidwell, RR; Geratz, JD; Dubovi, EJ Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin. J Med Chem 26:294-8 (1983) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50027288
Synonyms:
2-{4-[3-(4-Carbamimidoyl-phenoxy)-propoxy]-phenyl}-1H-benzoimidazole-5-carboxamidine | CHEMBL102148
Type:
Small organic molecule
Emp. Form.:
C24H24N6O2
Mol. Mass.:
428.4864
SMILES:
NC(=N)c1ccc(OCCCOc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=N)cc1
Structure:
Search PDB for entries with ligand similarity: