Target
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11
Ligand
BDBM50476002
Substrate
n/a
Meas. Tech.
ChEMBL_410136 (CHEMBL908306)
EC50
0.676083±n/a nM
Citation
 Altenbach, RJBrune, MEBuckner, SACoghlan, MJDaza, AVFabiyi, AGopalakrishnan, MHenry, RFKhilevich, AKort, MEMilicic, IScott, VESmith, JCWhiteaker, KLCarroll, WA Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener. J Med Chem 49:6869-87 (2006) [PubMed]  Article 
Target
Name:
ATP-binding cassette sub-family C member 9/ATP-sensitive inward rectifier potassium channel 11
Synonyms:
Potassium channel, inwardly rectifying, subfamily J, member 11/Sulfonylurea receptor 2 | Sulfonylurea receptor 2, Kir6.2
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 46128
Components:
This complex has 2 components.
Component 1
Name:
ATP-binding cassette sub-family C member 9
Synonyms:
ABCC9 | ABCC9_HUMAN | ATP-binding cassette transporter sub-family C member 9 | SUR2 | Sulfonylurea receptor 2 | Sulfonylurea receptor 2, Kir6.2
Type:
PROTEIN
Mol. Mass.:
174236.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_495672
Residue:
1549
Sequence:
MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
  
Component 2
Name:
ATP-sensitive inward rectifier potassium channel 11
Synonyms:
ATP-sensitive inward rectifier potassium channel 11 | IKATP | Inward rectifier K(+) channel Kir6.2 | KCJ11_HUMAN | KCNJ11 | Potassium channel, inwardly rectifying subfamily J member 11 | Potassium channel, inwardly rectifying, subfamily J, member 11 | Sulfonylurea receptor 1, Kir6.2 | Sulfonylurea receptor 2, Kir6.2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43549.41
Organism:
Homo sapiens (Human)
Description:
Potassium channel (ATP modulatory) 0 0::Q14654
Residue:
390
Sequence:
MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALTLASARGPLRKRSVPMAKAKPKFSISPDSLS
  
Inhibitor
Name:
BDBM50476002
Synonyms:
CHEMBL217511
Type:
Small organic molecule
Emp. Form.:
C16H11BrFNO4
Mol. Mass.:
380.165
SMILES:
OC1=C2C(C3=C(COCC3=O)N=C2CO1)c1ccc(F)c(Br)c1 |c:1,12,t:4|
Structure:
Search PDB for entries with ligand similarity: