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Target
Farnesyl diphosphate synthase
Ligand
BDBM25308
Substrate
n/a
Meas. Tech.
ChEMBL_423086 (CHEMBL910471)
IC50
1100±n/a nM
Citation
 Leon, A; Liu, L; Yang, Y; Hudock, MP; Hall, P; Yin, F; Studer, D; Puan, KJ; Morita, CT; Oldfield, E Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. J Med Chem 49:7331-41 (2006) [PubMed]  Article 
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
(2E,6E)-farnesyl diphosphate synthase | 2.5.1.10 | FPP synthase | Farnesyl diphosphate synthase | Geranyltranstransferase | ISPA_ECOLI | ispA
Type:
PROTEIN
Mol. Mass.:
32153.72
Organism:
Escherichia coli K-12
Description:
ChEMBL_102603
Residue:
299
Sequence:
MDFPQQLEACVKQANQALSRFIAPLPFQNTPVVETMQYGALLGGKRLRPFLVYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGLPTCHVKFGEANAILAGDALQTLAFSILSDADMPEVSDRDRISMISELASASGIAGMCGGQALDLDAEGKHVPLDALERIHRHKTGALIRAAVRLGALSAGDKGRRALPVLDKYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKSTYPALLGLEQARKKARDLIDDARQSLKQLAEQSLDTSALEALADYIIQRNK
  
Inhibitor
Name:
BDBM25308
Synonyms:
(1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosphonoethyl)phosphonic acid | bisphosphonate, 57
Type:
Small organic molecule
Emp. Form.:
C9H12N2O7P2
Mol. Mass.:
322.1483
SMILES:
OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O
Structure:
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