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Target
Reverse transcriptase
Ligand
BDBM50476895
Substrate
n/a
Meas. Tech.
ChEMBL_447797 (CHEMBL896806)
IC50
2.9±n/a nM
Citation
 Gagnon, A; Amad, MH; Bonneau, PR; Coulombe, R; DeRoy, PL; Doyon, L; Duan, J; Garneau, M; Guse, I; Jakalian, A; Jolicoeur, E; Landry, S; Malenfant, E; Simoneau, B; Yoakim, C Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. Bioorg Med Chem Lett 17:4437-41 (2007) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50476895
Synonyms:
CHEMBL232379
Type:
Small organic molecule
Emp. Form.:
C22H19Cl2N5O3S
Mol. Mass.:
504.389
SMILES:
CC(C)(C)c1ccc(c(Cl)c1)-n1nnnc1SCC(=O)Nc1ccc(cc1Cl)C#CC(O)=O
Structure:
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