Target
Presenilin-1
Ligand
BDBM50477920
Substrate
n/a
Meas. Tech.
ChEMBL_461557 (CHEMBL928698)
IC50
15±n/a nM
Citation
 Bergstrom, CPSloan, CPWang, HHParker, MFSmith, DWZheng, MHansel, SBPolson, CTBarber, LEBursuker, IGuss, VLCorsa, JABarten, DMFelsenstein, KMRoberts, SB Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase. Bioorg Med Chem Lett 18:175-8 (2008) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50477920
Synonyms:
CHEMBL404295
Type:
Small organic molecule
Emp. Form.:
C25H25Cl2N5O3S
Mol. Mass.:
546.469
SMILES:
C[C@H](CCCn1nnnc1-c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: