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Target
DNA topoisomerase 3
Ligand
BDBM50028354
Substrate
n/a
Meas. Tech.
ChEBML_54508
Ki
19000±n/a nM
Citation
 Wright, GE; Brown, NC Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem 23:34-8 (1980) [PubMed]  Article 
Target
Name:
DNA topoisomerase 3
Synonyms:
DNA topoisomerase III | TOP3_BACSU | topB
Type:
PROTEIN
Mol. Mass.:
81515.22
Organism:
Bacillus subtilis
Description:
ChEMBL_54525
Residue:
727
Sequence:
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQTLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSVFEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK
  
Inhibitor
Name:
BDBM50028354
Synonyms:
6-(4-Amino-3-methyl-phenylamino)-1H-pyrimidine-2,4-dione | CHEMBL54530
Type:
Small organic molecule
Emp. Form.:
C11H12N4O2
Mol. Mass.:
232.2386
SMILES:
Cc1cc(Nc2cc(=O)[nH]c(=O)[nH]2)ccc1N
Structure:
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