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Target
Phenylalanine-4-hydroxylase
Ligand
BDBM50028430
Substrate
n/a
Meas. Tech.
ChEBML_154856
Ki
200±n/a nM
Citation
 Henrie, RN; Lazarus, RA; Benkovic, SJ Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase. J Med Chem 26:559-63 (1983) [PubMed]  Article 
Target
Name:
Phenylalanine-4-hydroxylase
Synonyms:
PH4H_RAT | Pah | Phe-4-monooxygenase
Type:
PROTEIN
Mol. Mass.:
51817.61
Organism:
Rattus norvegicus
Description:
ChEMBL_154856
Residue:
453
Sequence:
MAAVVLENGVLSRKLSDFGQETSYIEDNSNQNGAISLIFSLKEEVGALAKVLRLFEENDINLTHIESRPSRLNKDEYEFFTYLDKRTKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEEKQTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYSVTEFQPLYYVAESFSDAKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCNALQKIKS
  
Inhibitor
Name:
BDBM50028430
Synonyms:
2-Amino-6-phenyl-7,8-dihydro-3H,6H-pyrimido[5,4-b][1,4]thiazin-4-one | CHEMBL423042
Type:
Small organic molecule
Emp. Form.:
C12H12N4OS
Mol. Mass.:
260.315
SMILES:
Nc1nc2NCC(Sc2c(=O)[nH]1)c1ccccc1
Structure:
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