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Target
Signal peptidase I
Ligand
BDBM50480486
Substrate
n/a
Meas. Tech.
ChEMBL_575371 (CHEMBL1027045)
IC50
13400±n/a nM
Citation
 Buzder-Lantos, P; Bockstael, K; Anné, J; Herdewijn, P Substrate based peptide aldehyde inhibits bacterial type I signal peptidase. Bioorg Med Chem Lett 19:2880-3 (2009) [PubMed]  Article 
Target
Name:
Signal peptidase I
Synonyms:
LEP_ECOLI | Leader peptidase I | SPase I | lepB
Type:
PROTEIN
Mol. Mass.:
35961.43
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_154169
Residue:
324
Sequence:
MANMFALILVIATLVTGILWCVDKFFFAPKRRERQAAAQAAAGDSLDKATLKKVAPKPGWLETGASVFPVLAIVLIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENALPVTYSNVEPSDFVQTFSRRNGGEATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDKQEGEWPTGLRLSRIGGIH
  
Inhibitor
Name:
BDBM50480486
Synonyms:
CHEMBL539137
Type:
Small organic molecule
Emp. Form.:
C29H50N6O8
Mol. Mass.:
610.7427
SMILES:
CCCCCCCCCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C=O |r|
Structure:
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