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Target
Presenilin-1
Ligand
BDBM50481089
Substrate
n/a
Meas. Tech.
ChEMBL_599754 (CHEMBL1048198)
IC50
0.260000±n/a nM
Citation
 Truong, AP; Aubele, DL; Probst, GD; Neitzel, ML; Semko, CM; Bowers, S; Dressen, D; Hom, RK; Konradi, AW; Sham, HL; Garofalo, AW; Keim, PS; Wu, J; Dappen, MS; Wong, K; Goldbach, E; Quinn, KP; Sauer, JM; Brigham, EF; Wallace, W; Nguyen, L; Hemphill, SS; Bova, MP; Bard, F; Yednock, TA; Basi, G Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors. Bioorg Med Chem Lett 19:4920-3 (2009) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50481089
Synonyms:
CHEMBL584330
Type:
Small organic molecule
Emp. Form.:
C22H18F3N3O4S
Mol. Mass.:
477.456
SMILES:
COC(=O)c1ccc2-c3n[nH]cc3C(C3CC3)N(c2c1)S(=O)(=O)c1ccc(cc1)C(F)(F)F
Structure:
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