Reaction Details Report a problem with these data
Target
Rho-related GTP-binding protein RhoC
Ligand
BDBM50481341
Substrate
n/a
Meas. Tech.
ChEMBL_604487 (CHEMBL1072732)
IC50
>100000±n/a nM
Citation
 Evelyn, CR; Bell, JL; Ryu, JG; Wade, SM; Kocab, A; Harzdorf, NL; Showalter, HD; Neubig, RR; Larsen, SD Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorg Med Chem Lett 20:665-72 (2010) [PubMed]  Article 
Target
Name:
Rho-related GTP-binding protein RhoC
Synonyms:
ARH9 | ARHC | RHOC | RHOC_HUMAN | Rho cDNA clone 9 | Rho-related GTP-binding protein RhoC
Type:
PROTEIN
Mol. Mass.:
22006.13
Organism:
Homo sapiens
Description:
ChEMBL_117031
Residue:
193
Sequence:
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL
  
Inhibitor
Name:
BDBM50481341
Synonyms:
CHEMBL591079
Type:
Small organic molecule
Emp. Form.:
C15H13ClN2O3
Mol. Mass.:
304.728
SMILES:
Clc1ccc(NC(=O)CONC(=O)c2ccccc2)cc1
Structure:
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