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Target
Stromelysin-3
Ligand
BDBM50482224
Substrate
n/a
Meas. Tech.
ChEMBL_638696 (CHEMBL1168920)
IC50
13200000±n/a nM
Citation
 Abdel-Mohsen, HT; Ragab, FA; Ramla, MM; El Diwani, HI Novel benzimidazole-pyrimidine conjugates as potent antitumor agents. Eur J Med Chem 45:2336-44 (2010) [PubMed]  Article 
Target
Name:
Stromelysin-3
Synonyms:
MMP11_MOUSE | Matrix metalloproteinase 11 | Mmp11
Type:
PROTEIN
Mol. Mass.:
55452.62
Organism:
Mus musculus
Description:
ChEMBL_106453
Residue:
492
Sequence:
MARAACLLRAISRVLLLPLPLLLLLLLLLPSPLMARARPPESHRHHPVKKGPRLLHAALPNTLTSVPASHWVPSPAGSSRPLRCGVPDLPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQMAPTSPAPTLSSQAGTDTNEIALLEPETPPDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGYAYFLRGHLYWKFDPVKVKVLEGFPRPVGPDFFDCAEPANTFR
  
Inhibitor
Name:
BDBM50482224
Synonyms:
CHEMBL1163280
Type:
Small organic molecule
Emp. Form.:
C30H24N8O3S
Mol. Mass.:
576.628
SMILES:
[O-][N+](=O)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc(SCc2nc3ccccc3[nH]2)nc(-c2ccccc2)c1C#N
Structure:
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