Reaction Details Report a problem with these data
Target
Bifunctional protein GlmU
Ligand
BDBM50483325
Substrate
n/a
Meas. Tech.
ChEMBL_708879 (CHEMBL1664948)
Ki
23±n/a nM
Citation
 Pereira, MP; Blanchard, JE; Murphy, C; Roderick, SL; Brown, ED High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU. Antimicrob Agents Chemother 53:2306-11 (2009) [PubMed]  Article 
Target
Name:
Bifunctional protein GlmU
Synonyms:
Bifunctional protein (GlmU) | GLMU_ECOLI | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU | yieA
Type:
Enzyme
Mol. Mass.:
49189.50
Organism:
Escherichia coli
Description:
P0ACC7
Residue:
456
Sequence:
MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGDLLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDAKPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADMKRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQSEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKNSVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSKAGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGATIAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
  
Inhibitor
Name:
BDBM50483325
Synonyms:
CHEMBL1652297 | Mac0029665
Type:
Small organic molecule
Emp. Form.:
C20H24N4O4S5
Mol. Mass.:
544.754
SMILES:
O=C(CSc1nnc(SCC(=O)NCCSCc2ccco2)s1)NCCSCc1ccco1
Structure:
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