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Target
Reverse transcriptase
Ligand
BDBM99893
Substrate
n/a
Meas. Tech.
ChEMBL_758401 (CHEMBL1811267)
IC50
6600±n/a nM
Citation
 Bode, ML; Gravestock, D; Moleele, SS; van der Westhuyzen, CW; Pelly, SC; Steenkamp, PA; Hoppe, HC; Khan, T; Nkabinde, LA Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg Med Chem 19:4227-37 (2011) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM99893
Synonyms:
US8501767, 96
Type:
Small organic molecule
Emp. Form.:
C20H19ClN4
Mol. Mass.:
350.845
SMILES:
Clc1ccccc1-c1nc2ccc(cn2c1NC1CCCCC1)C#N
Structure:
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