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Target
Solute carrier organic anion transporter family member 1B2
Ligand
BDBM50185127
Substrate
n/a
Meas. Tech.
ChEMBL_838789 (CHEMBL2077696)
Ki
6100±n/a nM
Citation
 Ismair, MG; Stanca, C; Ha, HR; Renner, EL; Meier, PJ; Kullak-Ublick, GA Interactions of glycyrrhizin with organic anion transporting polypeptides of rat and human liver. Hepatol Res 26:343-347 (2003) [PubMed]  Article 
Target
Name:
Solute carrier organic anion transporter family member 1B2
Synonyms:
Liver-specific organic anion transporter 1 | OATP-4 | Oatp1b2 | SO1B2_RAT | Slc21a10 | Slco1b2 | Sodium-independent organic anion-transporting polypeptide 4 | Solute carrier family 21 member 10 | Solute carrier organic anion transporter family member 1B2 | rLST-1
Type:
PROTEIN
Mol. Mass.:
76788.53
Organism:
Rattus norvegicus
Description:
ChEMBL_104153
Residue:
687
Sequence:
MDHTQQSRKAAEAQPSRSKQTRFCDGFKLFLAALSFSYICKALGGVVMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGSILTALPHFFMGYYKYAKENDIGSLGNSTLTCFINQMTSPTGPSPEIVEKGCEKGLKSHMWIYVLMGNMLRGIGETPIVPLGISYLDDFAKEGHTSMHLGTLHTIAMIGPILGFIMSSVFAKIYVDVGYVDLNSVRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFLPKIPKRSQEERKNSVSLHAPKTDEEKKHMTNLTKQEEQDPSNMTGFLRSLRSILTNEIYVIFLILTLLQVSGFIGSFTYLFKFIEQQFGRTASQANFLLGIITIPTMATAMFLGGYIVKKFKLTSVGIAKFVFFTSSVAYAFQFLYFPLLCENKPFAGLTLTYDGMNPVDSHIDVPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFRGDKKPNNTEFYDCSCISNSGNNSAHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSLILILMKSVQPELKSLAMGFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRLFGFSYLGLNLALKTPPLFLYVVLIYFTKRKYKRNDNKTLENGRQFTDEGNPDSVNKNGYYCVPYDEQSNETPL
  
Inhibitor
Name:
BDBM50185127
Synonyms:
(3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid | 30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-beta-D-glucopyranosyluronic acid)-alpha-D-glucopyranosiduronic acid | CHEMBL441687 | glycyrrhizic acid | glycyrrhizinic acid | glyzyrrhizin
Type:
Small organic molecule
Emp. Form.:
C42H62O16
Mol. Mass.:
822.9321
SMILES:
CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=O |r,t:18|
Structure:
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