Reaction Details Report a problem with these data
Target
Leukotriene B4 receptor 1
Ligand
BDBM50029468
Substrate
n/a
Meas. Tech.
ChEMBL_99490 (CHEMBL704378)
Ki
33±n/a nM
Citation
 Sawyer, JS; Bach, NJ; Baker, SR; Baldwin, RF; Borromeo, PS; Cockerham, SL; Fleisch, JH; Floreancig, P; Froelich, LL; Jackson, WT Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist. J Med Chem 38:4411-32 (1995) [PubMed]  Article 
Target
Name:
Leukotriene B4 receptor 1
Synonyms:
BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LT4R1_HUMAN | LTB4-R 1 | LTB4R | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37582.68
Organism:
Homo sapiens (Human)
Description:
Q15722
Residue:
352
Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
  
Inhibitor
Name:
BDBM50029468
Synonyms:
2-{3-[3-(5-Ethyl-4'-fluoro-2-hydroxy-biphenyl-4-yloxy)-propoxy]-2-propyl-benzoyl}-benzoic acid | CHEMBL139115
Type:
Small organic molecule
Emp. Form.:
C34H33FO6
Mol. Mass.:
556.6206
SMILES:
CCCc1c(OCCCOc2cc(O)c(cc2CC)-c2ccc(F)cc2)cccc1C(=O)c1ccccc1C(O)=O
Structure:
Search PDB for entries with ligand similarity: