Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50029770
Substrate
n/a
Meas. Tech.
ChEMBL_52984 (CHEMBL665253)
IC50
100±n/a nM
Citation
 Queener, SF New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. J Med Chem 38:4739-59 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50029770
Synonyms:
4-amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide | 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide | ACETYLSULFAMETHOXAZOLE | BACTRIM | CHEMBL443 | COTRIM | GANTANOL | GANTANOL-DS | RO 4-2130 | SEPTRA | SULFAMETHOPRIM | SULFAMETHOPRIM-DS | SULFAMETHOXAZOLE SODIUM | SULFATRIM | SULFATRIM-DS | SULFATRIM-SS | SULMEPRIM | SULPHAMETHOXAZOLE | TRIMETH/SULFA | UROBAK
Type:
Small organic molecule
Emp. Form.:
C10H11N3O3S
Mol. Mass.:
253.278
SMILES:
Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1
Structure:
Search PDB for entries with ligand similarity: