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Target
Dihydrofolate reductase
Ligand
BDBM50029764
Substrate
n/a
Meas. Tech.
ChEMBL_52981 (CHEMBL876710)
IC50
1500±n/a nM
Citation
 Queener, SF New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii. J Med Chem 38:4739-59 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50029764
Synonyms:
1,1'-sulfonylbis(4-aminobenzene) | 4,4'-Sulfonylbisbenzenamine | 4,4'-dapsone | 4,4'-diaminodiphenyl sulfone | 4,4'-sulfonylbisaniline | 4,4'-sulfonyldianiline | 4-aminophenyl sulfone | Bis(p-aminophenyl) sulfone | CHEMBL1043 | DADPS | DAPSONE | DDS | Diaphenylsulfone | p,p'-diaminodiphenyl sulfone | p,p-sulphonylbisbenzamine | p,p-sulphonylbisbenzenamine | p-aminophenyl sulfone
Type:
Small organic molecule
Emp. Form.:
C12H12N2O2S
Mol. Mass.:
248.301
SMILES:
Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1
Structure:
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